E01 Lead Research Scientist (Energetic Materials Synthesis) (PS)
Responsibilities
If you have the passion to research into the synthesis and characterization of new generation of highly energetic materials, the opportunity is now open for you. You will undertake research on synthesis and characterization of poly-nitro and azido containing compounds. You will also have the opportunity to travel overseas and conduct experimental research both in the lab and field with a team of experts. Training programme through a collaborative research attachment at an overseas defence institution will be provided too.
You will take the lead in synthesis of energetic materials and plan for its programme. If you are passionate and independent in research and wish to be a pioneer to help shape the future of the energetic materials research programme, we would like to meet you.
Requirements
• PhD or Master degree in organic synthesis or related area
• Experience and knowledge in the relevant field such as synthesising organic or polymer compounds will be an advantage
• Fresh graduate with a passion in energetic materials research are welcome to apply as overseas training will be provided whenever available |
E02 Immediate Vacancies available at the Laboratory of Animal Health Biotechnology
We are urgently seeking for candidates with PhD, MSc or BSc (Biotechnology, Biological Sciences or related fields) and with experience in at least one of the following:
1. Intensive molecular techniques such as gene cloning, gene expression in bacteria, yeast and/or mammalian system, transfection, in situ hybridisation and cDNA library construction.
2. Cell culture, monoclonal antibody production, various immunologic/virologic methods to study antibody and antigen reaction.
3. HPLC, affinity column work and flow cytometry.
4. Construct viral infectious clone and use viral vector to deliver gene into cell.
5. Construct bacterial mutants, characterisation of virulence factors for bacterial pathogenesis.
The salary given is commensurable to the educational qualifications and working experience of the selected candidate. Bonus is awarded based on individual's work performance. Other benefits include annual leave and medical insurance etc. |
E03 Group Leader, Computational Chemistry
Responsibilities:
The successful candidate will manage a team that supports all aspects of computational drug design and drug discovery informatics. Activities include combinatorial and focused library design, commercial compound acquisition, lead optimization, protein modelling, structural-based drug design and virtual screening.
Requirements:
- PhD in Computational Chemistry with at least 6 - 8 years of industry experience
- Demonstrated experience in small-molecule rational and structured-based drug design
- Expertise in pharmacophore modelling, QSAR analysis, protein-ligand interactions and focused library design;
- Ability to work in a UNIX environment and programming skills in C++ and Perl
- Strong communication, interpersonal and organisational ability
- Candidates with supervisory experience would have an advantage
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E04 Group Leaders and Senior Scientists
Expression Engineering
Our focus is to develop novel cell lines for high level recombinant protein expression. We are seeking individuals to develop molecular methods to extend culture viability by regulating apoptosis, improve glycoprotein quality and enhance productivity by designing novel expression systems. Experience in gene targeting techniques, e.g. gene knockdown, would be advantageous. You will be expected to lead in innovative high throughput methods of transfection and selection of stable clones.
Animal Cell Technology
Working with industrially important hosts, research activities are directed at designing proprietary chemically defined, protein-free media and feeding strategies to achieve high cell density cultures. Our interest is to develop a tool kit which would incorporate genomics, proteomics and metabolomics data from cell culture processes to engineer host cells with improved productivity. Experience in cell biology, metabolic engineering and/or bioinformatics will be desirable.
We would like to explore new and innovative technologies related to high throughput bioprocess systems such as microbioreactors, microfluidics and microsensors for parallel process development, monitoring and control.
Microbial Fermentation
We plan to expand our research using E. coli to produce antibody fragments. A challenge would be to develop strains capable of secreting protein at industrially viable yields. With experience in complex pathway engineering or mutagenesis, you will be in charge of constructing new/improved strains to produce active antibody fragments.
Stem Cells
Our team has established capabilities in human embryonic stem (hES) cell culture, developed immortal feeders and identified putative support factors to hES cells. With a particular interest in stem cell expansion, the successful applicant will be expected to lead in the development of methods and devices to scale up therapeutic quantities of hES cells, and advance the understanding of pluripotent stem cell maintenance.
Downstream Processing
Current DSP activities are focused on recombinant protein and plasmid DNA purification. We are looking to initiate research in process scale crystallisation of antibodies/antibody fragments and to develop in-house expertise in protein stabilisation and formulation. Candidates familiar with cGMP regulatory guidelines would be preferred. Complementary to DSP, we are seeking individuals keen to advance the fundamental understanding of protein stabilisation and crystallisation, with experience in protein modeling.
Analytics, Proteomics and Microarray Laboratories
We are seeking candidates with expertise in these platform technologies to develop chemometrics, quantitative proteomics and genomics techniques to monitor cell culture processes for metabolic flux analysis studies.
We are also interested in applicants with experience in the development of quantitative ELISA and functional assays and who are familiar with testing for final product release.
Candidates should hold a PhD, preferably with at least 5-8 years research experience and a proven track record of publications in their chosen field. An attractive remuneration package commensurate with qualifications will be offered. |
E05 Electrical Engineer (Auditory Research Group)
We are searching for electrical engineers to conduct research on the middle and inner ear. A wide variety of electrophysiological experiments will be conducted in specially built hemi-anechoic chambers, generating output signals such as evoked potentials, laser interferometer, hydrophone pressure sensor etc. These experiments will help in the understanding of auditory physiology and will assist in the design of middle ear reconstruction prostheses and implantable hearing devices.
Applicants should have a PhD in Electrical Engineering or a related fields, with a particular emphasis on electrophysiology. Those with the relevant expertise, but no prior experience in hearing research, are also encouraged to apply. Successful candidates will be expected to design and develop specialized systems and circuits for electrophysiological experiments. They will also customize testing apparatus to facilitate the research, and help calibrate and maintain the highly specialized equipment used by the Group. |
E06 Mechanical Engineer (Auditory Research Group)
We are on the look-out for mechanical engineers to undertake research projects on middle and inner ear modeling. They will focus on mathematical and computational modeling of the middle and inner ear structures and their work will be verified by experimental measurements using laser interferometer systems in specially built hemi-anechoic chambers. These experiments will help in the design of middle ear reconstruction prostheses and implantable hearing devices.
Applicants should have a PhD in Mechanical Engineering or a related field with a particular emphasis on mathematical and computational modelling. Individuals with the relevant expertise, but no prior experience in hearing research, are also encouraged to apply. Successful applicants will be expected to develop computational models to describe the 3-D motion of the middle ear ossicles and to help in the design of ossicle reconstruction prostheses for fabrication and use in clinical trials. |
E07 Psycho-Acoustician (Auditory Research Group)
We are inviting enthusiastic research personnel to join us in conducting research on free-field and directional hearing tests. They will pioneer research in understanding how the human brain analyzes and processes complex sounds in the auditory system. Psycho-acoustical tests will be performed in a specially built hemi-anechoic chamber, equipped with specialized speaker booms to support comprehensive testing. These experiments will help us understand the benefits of directional cues in auditory processing and help assess the benefits of bilateral fittings of hearing devices such as hearing aids, bone-anchored devices and cochlear implants.
Applicants should have a PhD in Experimental Psychology or a related field, with a particular emphasis on psychometric auditory research. Successful applicants will be expected to develop experimental protocols for testing free-field auditory performance of hearing aids and devices. They will also conduct directional testing to assist in the clinical trials of devices and prostheses |
E08 Research Scientist (Auditory Research Group)
We are looking for young research scientists to be involved in research projects on cellular and molecular mechanisms of age-related disorders. They will test various bioactive compounds such as antioxidants, human growth factors and neurotrophic factors in vivo to find out how these compounds can slow down the aging process. They will also examine how mitochondrial and DNA maintenance mechanisms as well as the auditory system are involved in the prevention of aging.
Applicants should have a PhD in Molecular Biology or a related field, with a particular emphasis on DNA analysis, molecular bioassay, cell transfection technology, immunocytochemistry and electrophysiology. Individuals with relevant expertise in studies on antioxidants, human growth factors and/or DNA maintenance are encouraged to apply. Successful applicants will be expected to develop techniques for investigating DNA stabilization and mitochondria maintenance mechanisms at the cellular and molecular levels after delivery of the compounds.
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E09 Research Group Leader (Ref code: 970-SM)
Responsibilities
As Research Group Leader, you will recruit and lead a group of scientists dedicated to developing and implementing new cell-based assays for micro-RNA drug discovery
Requirements
- PhD in molecular biology or related field and 5+ years experience or equivalent
- Substantial supervisory experience leading highly productive groups of 4-10 scientists in an academic or industrial setting
- Outstanding leadership, communication, and written skills
- A proven track record of accomplishment as reflected by candidate's publication in peer-reviewed journals
Experience in drug discovery research is desired |
E10 Molecular Biologists (Hematology and Oncology Research) [Ref code: 969-SM]
Responsibilities
Successful candidates will be part of a fast-paced team exploiting the newest field of RNA biology (miRNA) for drug discovery and will develop in vitro bioassays for assessing the molecular pharmacology of miRNA functions in hematopoiesis and cancer
Requirements
- Ph.D. or M.D. with 0-4 years post-graduate experience or equivalent
- Experience in cell culture, transfection, mRNA analysis and cell-based assay development
- Must be creative, team-oriented and able to work independently
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